Glucose should be monitored (before feeding) in high-risk infants at 2,4,6,12,24, and 48 hours after birth. The lack of strong evidence in the published literature of an absolute glucose threshold value to define neonatal hypoglycemia and the utilization of higher blood glucose values without strong evidence to support their use has failed to clarify a clinically significant definition for hypoglycemia. The development of operational thresholds ,a level at which clinical intervention should be initiated, is one alternative. Original work