Alternatively, the channel could have
overcome the destabilizing electrostatic
effects of the bilayer center by lining the
entire pore with a polarizable surface, putting
ion binding sites along its entire
length. But the structure shows that, with
the exception of the selectivity filter, the
pore lining is mainly hydrophobic, a general
property of K1 channels (Fig. 1). This
conclusion was anticipated by the landmark
experiments of Armstrong, which
showed that hydrophobic cations bind in
Alternatively, the channel could haveovercome the destabilizing electrostaticeffects of the bilayer center by lining theentire pore with a polarizable surface, puttingion binding sites along its entirelength. But the structure shows that, withthe exception of the selectivity filter, thepore lining is mainly hydrophobic, a generalproperty of K1 channels (Fig. 1). Thisconclusion was anticipated by the landmarkexperiments of Armstrong, whichshowed that hydrophobic cations bind in
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