Advantages of tumblers with blades:
Baffles are useful for both wet and dry mixing.
Wide range of shearing force can be applied with agitator bars permitting the intimate mixing of very fine as well as coarse powders.
Serial dilution is not needed when incorporating low-dose active ingredients.
Disadvantages of tumblers with blades:
Attrition is large, size reduction of friable particles results.
Scale-up can prove a problem, because general principles of scale-up do not work
Cleaning may be a problem, because agitator assembly must be removed and the packing should be replaced for a product changeover
Potential packing (sealing) problems occur.