The purpose of this review of literature was to identify effective instructional strategies in lower elementary general education classrooms to improve the reading skills of students with Autism Spectrum Disorder (ASD). The literature reviewed included studies focusing on elementary students diagnosed with ASDs and different reading instruction strategies. Results and conclusions from the studies indicated the effectiveness of direct instruction, small group instruction, assistive technology, and peer tutoring with each group of participants. Recommendations for improving the effectiveness of reading skill instructional strategies for students with ASD in elementary general education classrooms include using a balanced approach of the discussed strategies and understanding that there is no single best practice reading instruction strategy that will work for all children with ASD.