Preliminary data show that HNE or ONE covalently bound to PC (9-hydroxy-12- oxo-10-dodecenoyl-PC, HODA-PC or 9,12-oxo-10-dodecenoyl-PC, ODA-PC, respectively) has much less cellular toxicity compared to the diffusible electrophiles alone (Fig. 2).
Preliminarydata show that HNE or ONE covalently bound to PC (9-hydroxy-12-oxo-10-dodecenoyl-PC, HODA-PC or 9,12-oxo-10-dodecenoyl-PC,ODA-PC, respectively) has much less cellular toxicity compared tothe diffusible electrophiles alone (Fig. 2).