Eighteen sites were considered in this study, which reflectedall major agro-ecological zones of Central Asia suitable for wheatcultivation; rainfed (spring) wheat production predominating inthe north of Kazakhstan and irrigated cropping in the more aridsouth of Central Asia. Results revealed rather complex interac-tions between a range of agronomic factors (irrigation fertilizerapplication), wheat varieties under study, biophysical site-specificattributes (groundwater, soil salinity), factors related to climatechange (warmer winters, hotter flowering periods) and interrelatedcrop phenological/growth characteristics, such as a shortening ofcropping period or a shift in time of flowering. Varying levels ofagronomic management added to the complexity. Our simulationresults thus – even though unprecedented in terms of magnitudeof considered impact factors – provide only a snapshot of the vastpossible scenarios addressing the impact of CC. We believe thatthe complexity of presented results is a strong indication for thenecessity to improve global-scale CC impact studies in terms ofcrop varieties considered, presumed agronomic management andabiotic conditions.