Only two patients with pulmonary TB did not undergo directly observed therapy (DOT), which was strictly related to accessibility difficulties. Neither of the patients with genitourinary and cutaneous TB and none of the patients with LTBI were treated with DOT strategy. Ultimately, a total of 36 patients (65.5%), 28 with pulmonary TB, all 5 patients with lymphatic TB and all 3 patients with pleural TB, were submitted to DOT.