This phenomenon is strictly dependent on tpresence of lipid in the diet
[22]
. It takes place mainly at the oral
level since a direct oil deposition onto the tongue is suf
fi
cient to
trigger the drop of CD36 protein in CVP
[22]
. As reported for
numerous surface receptors, this negative feedback might consti-
tute a desensitization system during persistent exposure to dietary
lipids. Interestingly, the magnitude of the CD36 drop in the CVP
seems suf
fi
cient to induce a decrease in the preference for lipids
[22]
. Therefore, it is tempting to speculate that this change might
modulate the motivation for fat during a meal, initially high and
thengraduallydecreasing duringthe food intake.This physiological
negative feedback is reminiscent of sensory-speci
fi
c satiety which
refers to a temporary decline in pleasure derived from consuming a
certain food in comparison to other unconsumed foods
[23]