Invasive candidiasis remains a major cause of morbidity and mortality. It is now well known that an early diagnosis contributes to the
patients' outcome. Blood cultures, which are the first-line test in case of bloodstream infection suspicion, can be carried out using fungusselective medium (containing antibiotics) or standard microorganism medium allowing both bacterial and fungal growth. Some patients can
suffer from polymicrobial sepsis involving bacteria and yeasts, so we decided to investigate in blood cultures the influence of the presence of
bacteria on fungal development. Simulated blood cultures were performed using Candida albicans or C. glabrata coincubated with
Escherichia coli or Staphylococcus aureus at different concentrations. The results showed that, in a standard microorganism medium,
bacterial growth could hide the fungal development. Thus, in patients at risk of invasive candidiasis, the use of a specific fungal medium
could improve the diagnosis and allow an earlier efficient antifungal treatment.