While the acute kidney-related effects associated with the use of NSAIDs have been extensively
investigated, the chronic kidney-related effects of NSAIDs are not. However, the findings of
this study show a differential risk of chronic renal damage across individual NSAIDs. Longterm
exposure to NSAIDs with the longest half-life, such as oxicams, is associated with an increased
risk of CKD. Likewise, short-term use of ketorolac is also associated with an increased
risk of CKD, probably acting as a trigger of renal function deterioration in patients with subclinical
CKD.
While the acute kidney-related effects associated with the use of NSAIDs have been extensivelyinvestigated, the chronic kidney-related effects of NSAIDs are not. However, the findings ofthis study show a differential risk of chronic renal damage across individual NSAIDs. Longtermexposure to NSAIDs with the longest half-life, such as oxicams, is associated with an increasedrisk of CKD. Likewise, short-term use of ketorolac is also associated with an increasedrisk of CKD, probably acting as a trigger of renal function deterioration in patients with subclinicalCKD.
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