There were no significant effects of temperature on GtH-II release responses between 20°C and 25”C, and 10°C and 15°C. With continuous administration of 1 or 10 nM sGnRH-A, the initial GtH-II response peaks at the onset of continuous administration, and GtH-II release rates during each hour of continuous sGnRH-A treatment were always greater at the warmer temperature. dosage.