College students often live stressful lives, yet some college students appear to adapt better than their peers in similar situations. Active coping appears to be a vital factor that contributes to a successful adaptation. This study explored relative effectiveness among stress, secure attachment, and the trait of resilience in predicting active coping in high, general, and low stress situations. General stress situations are referred to as a combination of high and low stress situations. Multiple regression were applied to explore effective predictors of active coping. Whereas stress was not significantly correlated with active coping, the trait of resilience was the most effective predictor of active coping in high, general, and low stress situations. Secure attachment was an effective predictor of active coping in general situations but not in high or low stressful situations. Two-way ANOVA was applied to detect interaction effect of stress and the trait of resilience on active coping. No interaction effect of stress and resilience on active coping was found. Findings suggest that counselors can help college students to actively cope with stressful situations by enhancing more students’ resilience than their secure attachment, regardless of students’ stress levels. College life is composed of different stressful situations. Studies have shown that stressful situations college students are likely to encounter are related to academics, relationships, or work