The effort to improve economical value of Physic nut (Jatropha curcas L.) is by selection of non- toxic physic nut variety. The benefit is expected from other plant organs beside seeds (leaf and seed milk as a feed) and Crude Jatropha Oil (CJO) as the edible oil. The objective of this experiment was obtain toxicity level test of Wangi variety and local physicnut on the white rats (Rattus norvegicus). The methods used in this experiment are 1) observation of the rat’s liver tissue damages on the level of food mixture of 0.5 g, 0.75 g and 1 g/rats respectively for 2 physic nut varieties.. This observation is done on the rat’s liver tissue damages after 1 and 2 weeks of treatments. Toxicity level of Wangi variety’s seeds on white rats (Rattus norvegicus) is lower compare with local variety. White rats with local physic nut feed have more pycnosis and hyperchromatic (liver tissues damages) compared with rats feed by Wangi variety under the same dosage. This similar phenomenon showed on each level of dosage given to the white rat. From this experiment, It is concluded that Wangi variety has smaller toxicity level on animal experiment compare to the local variety, however, more advance research is needed on Wangi variety to determine its potential to use as the alternative of edible oil.
Key word: Jatropha curcas “Wangi variety”, toxicity, Rattus norvegicus.