To assess an electronic interactive sun protection program for kidney transplant recipients inclusive of users with inadequate and marginal health literacy. Methods: The program was delivered by tablet personal computers to Non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic/Latino (H/L) kidney transplant recipients (KTRs) in a randomized controlled trial. Skin cancer and sun protection knowledge were assessed at baseline and during the educational program. Results: Participants (n=170, 60 NHW, 48 H/L and 62 NHB) had similar baseline knowledge of skin cancer and sunscreen use. The mean duration of use was 27 min. Inadequate health literacy in 28% of KTRs was associated with H/L KTRs (45/48) (χ2, p < 0.05) and marginal health literacy was associated with NHB KTRs (45/62) (χ2, p