In low-grade progressive gliomas, neoadjuvant chemotherapy may be proposed in selected cases (eg, oligodendrogliomas
with 1p chromosome deletion) to postpone radiotherapy and to avoid cognitive sequelae in this population, which is often young, socially active, and has a long life expectancy. A recent study performed on lowgrade glioma patients showed that cognitive impairment was mostly the result of the use of AEDs [8].