In the last few years, a number of reports have demonstrated the antiproliferative effects of several compounds derived from garlic. The effects displayed by garlic derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction, all of which are cancer-reducing events (20,21). In the present study, the apoptosis of SGC-7901 cells increased significantly in a dose-dependent manner following treatment with ABGE. These data are in agreement with those of previous studies. Organosulfur compounds (OSC), components of garlic extraction, can suppress growth of cancer cells of different anatomical locations and modulate a number of key elements in cellular signal transduction pathways related to the apoptotic process (22). In the tumor-bearing mouse model, administration of ABGE effectively suppressed the development of inoculated tumor cells, indicating that ABGE also plays an anticancer role in vivo. Several early studies focused on the analysis of the effects of treatment with garlic or its components on the tumorigenic capabilities of the inoculated tumor cells in test animals. In these studies, reduced tumor growth and increased survival were also observed (23,24).