Using highly porous biodegradable matrices in the shape of the desired bone, with cells and signaling molecules (e.g., protein growth factors), then culturing and implanting the scaffolds into the defect to direct the growth of new bone.
The goal: Create bone tissue that can be used to repair skull defects (scaffolding)
The challenge: Find the perfect stiffness and porous structure that memics the bone and generates strains and stimulates the bone cells to form new bone.