Clancy et al. (22) showed that Candida species other than C. albicans also produced extracellular phospholipases, however, at lower levels than those secreted by C. albicans. Such difference can be attributed to variations in the isolates or differences in the medium preparation or in the substrate employed for phospholipase detection. Ghannoum (40), in an excellent review about the role of phospholipases on virulence and pathogeny of several fungus genera including Candida, suggested that fungal phospholipases can be evaluated as possible therapeutic effects.