There was no consistent evidence of a benefit of Ginkgo biloba in the treatment of neuropsychiatric symptoms. However, the presence of psychological or behavioral symptoms in dementia may be an effect modifier. Two studies that included patients with neuropsychiatric features yielded a clinically relevant effect in this outcome domain. Based on our results, no solid conclusions can be given for quality of life. Subgroup analyses showed that a dosage of 240 mg of ginkgo might be necessary to yield clinically relevant effects.