with a similar efficiency to that of deferasirox. The presence of
albumin has no observable influence on deferitazole-induced
mobilization of iron from citrate, whereas with deferasirox
there is appreciable inhibition, particularly from the oligomeric
iron citrate complex 7. This difference is most likely
associated with the degree of binding of deferitazole and
deferasirox to albumin (86% and >99%, respectively). On the
other hand, once formed, the FeIII(deferitazole)2 complex is
sufficiently stable not to donate any detectable iron to either
citrate or apotransferrin when incubated at physiological concentrations
for 24 h. Thus the complex is unlikely to facilitate
the redistribution of iron and once formed will be excreted in
either the urine or the bile.