was designed to assess the effect of once-daily empagliflozin treatment on the progression of kidney disease and cardiovascular disease and to examine the safety profile of the drug in a wide range of patients with CKD. The trial aimed to include large numbers of patients without diabetes, patients with an eGFR of less than 30 ml per minute per 1.73 m2 , and patients with low levels of proteinuria, as measured by the urinary albumin-to-creatinine ratio