Bio markers for adipose tissue , namely adiponectin and leptin, changed from their baseline when measured on day 29 in this dose group. The authors reporteda 51 % increase in adiponectin and a 28 % decrease in leptin.This is biologically plausible as adiponectin and body fat massare negatively correlated whereas leptin and adipose tissue arepositively correlated. No statistically significant differences inbiomarkers or fat mass were found in the lower 1 mg/kg dosinggroup