Jardines del Rey developed on the coral reef system that lines Cuba's shore, between the Atlantic Ocean, the Bay of Buena Vista and Bay of Jiguey. The reef, part of the Sabana-Camaguey Archipelago, extends for two hundred kilometres (120 miles) on a north-west to south-east direction.
Jardines del Rey Airport is located on Cayo Coco. Additional access to Cayo Coco and Cayo Guillermo is by a causeway that connects the islands to mainland Cuba.