Several dietary factors and lifestyle factors are likely
to have a major influence on the risk of colorectal cancer. Overconsumption of energy is likely to be on
of the major contributors to the high rates of this kind
of cancer in Western countries17, 18.
Because many case-control studies that found an
association with total energy intake, the apparent association
with dietary fat could be due, at least in part,
to total energy intake19.
There is a considerable interest in the relationship
between total caloric intake and colorectal cancer risk.
Evidence in laboratory animals indicates that the effect
of high caloric intake on colorectal cancer risk is
independent of total dietary fat20 and has provided that
caloric restriction inhibits chemically induced colon
tumor incidence by about 20%-40% over the incidence
rates observed in animals fed ad libitum21.
Rouillier et al in a case-control study concluded that
a low-energy diet appeared as protective all along the
adenoma-carcinoma sequence, contrary to a highenergy,
high-processed meat and alcohol diet22.