Unprecedented capabilities for the detection of nuclear particles via tailored resonant acoustic systems such as the acoustic tensioned metastable fluid detection (ATMFD) systems were assessed for determin- ing directionality of incoming fast neutrons. This paper presents advancements that expand on these accomplishments, thereby increasing the accuracy and precision of ascertaining directionality informa- tion utilizing enhanced signal processing-cum-signal analysis, refined computational algorithms, and on demand enlargement of the detector sensitive volume. Advances in the development of ATMFD sys- tems were accomplished utilizing a combination of experimentation and theoretical modeling. Modeling methodologies include Monte-Carlo based nuclear particle transport using MCNP5 and multi-physics based assessments accounting for acoustic, structural, and electromagnetic coupling of the ATMFD sys- tem via COMSOL’s multi-physics simulation platform. Benchmarking and qualification studies have been conducted with a 1 Ci Pu–Be neutron-gamma source. These results show that the specific ATMFD sys- tem used for this study can enable detection of directionality of incoming fast neutrons from the neutron source to within 30◦ with 80% confidence; this required ∼2000 detection events which could be collected within ∼50 s at a detection rate of ∼30–40 per second. Blind testing was successfully conducted for deter- mining the neutron source randomly positioned in space. Results of experimentation were found to be compatible with MCNP5-COMSOL multi-physics model predictions.