To evaluate the motor and emotional state, an open-field test was performed. The following parameters were evaluated for 5 min: locomotion or crossings (number of line crosses), rearings (the number of times the mouse stands on its hind legs), grooming (the number of times the mouse “washes” itself by licking during the observation period) and time spent in the central area. The equipment was made of white colored wood, and it consisted of a quadrilateral with a rectangular area of 4830.25 cm2 and walls 34.5 cm high, with the base subdivided into sixteen quadrants