Glycyrrhizin is a chief constituent of licorice root and is a sweet tasting triterpenoid saponin. Licorice is a perennial plant that grows in southern Europe, Asia, and the Mediterranean. The dried roots and underground stems of the plant are used in herbal remedies. Glycyrrhizin along with its aglycone and glycyrrhetinic acid have also been stated to encourage activity of interferon, supplement the movement of natural killer cells and modulate the growth response of lymphocytes through augmentation of IL-2 production [32,35-37]. Experimental studies have recognized number of substances in licorice that may help avert DNA mutations, reduce tumor development, or even destroy cancer cells including breast cancer, prostate cancer, and leukemia cells. In studies with mice, glycyrrhizin and glycyrrhizic acid decreased the initiation of colon, liver, uterine, and breast cancers [32]. Licorice root also contains powerful antioxidants, as well as certain phyto-estrogens that can perform some of the functions of the body's natural estrogens. Research has demonstrated that this estrogenic effects of licorice components help to slow the progression of breast cancer [38,39]. Other studies have further shown that the bioactive compounds of licorice may be chemopreventive in other cancers, including prostate cancer.