The purpose of the present manuscript was to describe the strategies we found helpful in recruiting and retaining children with CHC in a treatment trial of 24 to 48 weeks of therapy as well as two annual follow up visits after discontinuation of treatment. We learned that simply recruiting patients within our own centers was not sufficient to achieve target enrollment within the target time frame and that extra efforts were needed. These efforts are described as the strategies utilized to achieve high retention rates (84% at the 2 year follow up).