1. Introduction
Diabetes mellitus is caused by impaired insulin production and/or by decreased tissue response to the insulin[1]. The number of people with diabetes is increasing worldwide; 366 million people have diabetes, and 552 million people are expected to have diabetes by 2030[2]. During the pathogenesis of diabetes, mononuclear cells, infiltrating in and around the islets, generate excessive cytokines that upregulate inducible nitric oxide synthase (iNOS) expression and subsequently NO production, which impaires insulin secretion[3]. Insulin is a potent inducer of adipogenesis and enhances glucose uptake through activation of insulin