. Is Mrs. S suffering from adrenal cortical insufficiency or adrenal cortical hypersecretion?This article will describe adrenal cortical insufficiency (also called Addison disease) and adrenal cortical hypersecretion (also called hypercortisolism and Cushing syndrome), and explain how to recognize and manage these conditions. For more on signs and symptoms, see Recognizing two adrenal disorders and Lab findings for patients with adrenal disorders.The adrenal glands are highly vascular, tent-shaped organs located on top of the kidneys. The outer portion is known as the cortex while the inner portion is the medulla. Each portion has independent glandular functions.