Cardiovascular disease, endothelial dysfunction, and oxidative stress are common complications among
patients with type 2 diabetes (T2DM). In addition to the average blood glucose concentration, glycemic variability may be
an important factor for the development of chronic diabetes complications. Patients with T2DM are treated with various
types of oral glucose-lowering drugs. Exercise is considered to benefit the health of both healthy and unhealthy
individuals, which has been confirmed by a number of scientific research studies in which the participants’ health
improved. Our general aim in this study will be to evaluate glucose variability after submaximal exercise test in patients
receiving treatment with either vildagliptin or glibenclamide. The specific aims of this study are to evaluate the oxidative
stress, endothelial function, and metabolic and cardiovascular responses to exercise under treatment with vildagliptin or
glibenclamide. All these responses are important in patients with T2DM.
Cardiovascular disease, endothelial dysfunction, and oxidative stress are common complications among
patients with type 2 diabetes (T2DM). In addition to the average blood glucose concentration, glycemic variability may be
an important factor for the development of chronic diabetes complications. Patients with T2DM are treated with various
types of oral glucose-lowering drugs. Exercise is considered to benefit the health of both healthy and unhealthy
individuals, which has been confirmed by a number of scientific research studies in which the participants’ health
improved. Our general aim in this study will be to evaluate glucose variability after submaximal exercise test in patients
receiving treatment with either vildagliptin or glibenclamide. The specific aims of this study are to evaluate the oxidative
stress, endothelial function, and metabolic and cardiovascular responses to exercise under treatment with vildagliptin or
glibenclamide. All these responses are important in patients with T2DM.
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