On the other hand, controlled clinical trials in humans demonstrated no benefit when aloe vera was incorporated into topical therapy13, and one study demonstrated delayed wound healing when aloe vera was incorporated14. Many of the inconsistent clinical results obtained for the therapeutic efficacy of aloe gel might have been caused by the history of the sample after removal from the leaf, or even the growing conditions of the plant15. No studies have yet been undertaken to determine the effect of aloe gel on the clinical signs and biochemical changes of cutaneous aging and photoaging.