Although both Thai traditional massage and Thai herbal compress are growing in popularity among Thai general public, the evidence-based data supporting their potential role for treating Osteoarthritis of the knee has been still limited and warrants further intensive investigation; this study aimed to explore the clinical responses and safety of noth modalities in short-term symptomatic treatment of osteoarthritis of the knee in comparision to oral ibuprofen, a nonsteroidal anti-inflammatory drug