The effectiveness of G. biloba extract in the treatment of intermittent
claudication (peripheral arterial occlusive disease Fontaine stage II), as compared
with a placebo, was demonstrated in placebo-controlled, double-blind
clinical trials by a statistically significant increase in walking distance (1, 23, 24).
Sixty patients with peripheral arterial occlusive disease in Fontaine stage IIbwho were treated with the drug (120–160mg for 24 weeks) and underwent
physical training also clearly increased their walking distance (25).
Out of 15 controlled trials (up to the end of 1990) only two (23, 24) were of
acceptable quality (22–24). The results of both studies were positive and
showed an increase in walking distance in patients with intermittent
claudication after 6 months (23), and an improvement of pain at rest in patients
treated with 200 mg of G. biloba extract for 8 weeks (24).
After meta-analysis of five placebo-controlled clinical trials (up to the end of
1991) of G. biloba extract in patients with peripheral arterial disease, investigators
concluded that the extract exerted a highly significant therapeutic effect
(26).
The effectiveness of G. biloba extract in the treatment of intermittentclaudication (peripheral arterial occlusive disease Fontaine stage II), as comparedwith a placebo, was demonstrated in placebo-controlled, double-blindclinical trials by a statistically significant increase in walking distance (1, 23, 24).Sixty patients with peripheral arterial occlusive disease in Fontaine stage IIbwho were treated with the drug (120–160mg for 24 weeks) and underwentphysical training also clearly increased their walking distance (25).Out of 15 controlled trials (up to the end of 1990) only two (23, 24) were ofacceptable quality (22–24). The results of both studies were positive andshowed an increase in walking distance in patients with intermittentclaudication after 6 months (23), and an improvement of pain at rest in patientstreated with 200 mg of G. biloba extract for 8 weeks (24).After meta-analysis of five placebo-controlled clinical trials (up to the end of1991) of G. biloba extract in patients with peripheral arterial disease, investigatorsconcluded that the extract exerted a highly significant therapeutic effect(26).
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