Piper betle L. (Piperaceae) leaves which are traditionally used in India and China in the prevention of oral malodor was examined
by bioassay-guided fractionation to yield allylpyrocatechol (APC) as the major active principle which showed promising activity
against obligate oral anaerobes responsible for halitosis. The biological studies with APC indicated that the potential to reduce
methylmercaptan and hydrogen sulfide was mainly due to the anti-microbial activity as established using dynamic in vitro models.
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