3.1. Methods development for global analysis of proteins adducted by
phospholipid-derived lipid electrophiles
Modification of cellular proteins is considered to play a significant
contribution to the role of lipid electrophiles in the progression of disease.
Additionally, in order to completely understand the effects of
HNE on cell biology, it is important to clearly define its protein targets.
While HNE has been identified as a significant modulator of
cell function and signaling, limited work has been done to in identify
the critical protein mediators underlying HNE's multifarious cellular