Oxidative stress appears to be involved in the ‘‘hit’’process, which promotes lipid peroxidation and the inflammatory response. Uric acid reflects the rate of cell renewal, which in itself can be a part of the inflammatory process, making it a pro-inflammatory factor. Uric acid increases interleukin (IL)-6 and tumor necrosis factor alpha (TNF-) levels. Thus, high levels of uric acid in blood are due
to oxidative stress that occurs in response to metabolic disorders