Fig. 4(I) shows a statistically significant difference (week 8 compared to the baseline) in both groups A and B towards a decrease of the total lesion count (P < 0.001). The TLC in group A was 37.165 ± 9.28 (baseline) and 19.63 ± 6.36 (Wk 8), (P = 0.003), and 32.60 ± 9.32 (baseline) and 18.33 ± 5.56 (Wk 8) for group B (P = 0.022).
We report a representative case of a 15-year-old female patient, whose acne lesions remarkably improved after topical application of SP-NLC gel for 8 weeks (Fig. 5).