Hi Natalie.
Welcome to Etsy I tried having two shops but seems one got more neglected than the other. There are many shops with a modge podge of items, and it can work with proper sections and arrangement of shop. As Stacy says I wouldn't put a stuffed elephant in with jewelry, but if your items are somewhat like it can work out. I just now started putting crochet items in back of shop, a nice feature is rearranging your shop. Of course it is up to you but I would start with one shop so as not to be over whelmed, it is a lot of work listing taking photos etc. Also it would mean double the social media "work." Good luck, oh and if you decide on two shops remember you have to link on each shop..