The results of our stratification analysis for the SNPs of Nalp3 are presented in Table 4.
Among subjects younger than 70 years old, individuals with the CC genotype of IVS8-
7652A>C in Nalp3 had a lower risk of silicosis than individuals with other genotypes (OR
[95%CI] = 0.24[0.06–0.88]). Among subjects older than 70 years, individuals with the T allele
of Ex4-849C>T in Nalp3 had a higher risk of silicosis than those with other genotypes (OR
[95%CI] = 2.52 [1.04–6.12]); the T allele was also associated with a higher risk of silicosis in
smokers (OR [95%CI] = 2.57 [1.11–5.93]).
The results of our stratification analysis for the SNPs of IL-1β are presented in Table 5. We
did not observe any significant interactions between the 2 SNPs in IL-1β and CDE, age, or
smoking status