Drug therapy is usually not rewarding in pets with megaesophagus. Drugs that may be attempted include metoclopramide or cisapride. These drugs are prokinetic agents which have a stimulating effect on the smooth muscle of the gastrointestinal tract. Because the dog’s esophagus is made of skeletal muscle, these drugs generally do not work in our canine patients but can certainly be tried, and may help relax the sphincter between the lower esophagus and the stomach which would be beneficial.