Spores and crystalline insecticidal proteins produced by B. thuringiensis have been used to control insect pests since the 1920s and are often applied as liquid sprays.[19] They are now used as specific insecticides under trade names such as DiPel and Thuricide. Because of their specificity, these pesticides are regarded as environmentally friendly, with little or no effect on humans, wildlife, pollinators, and most other beneficial insects and are used in Organic farming,[20] however the manuals for these products do contain many environmental and human health warnings,[21][22] and a 2012 European regulatory peer review of 5 approved strains found that while there is data to support some claims of low toxicity to humans and the environment, there is insufficient data to justify many of these claims.