1. dose the tablet preparation break up in the stomach to release the microgranules
2. when does release of 5-ASA from the mocrogranules begin, and at what location in the gastronitestinal tract
3. dose food alter the gastrointestinal transit of the microgranules and subsequent release of 5-ASA
4. is 5-ASA released in both the small and large intestine as suggested from previous clinical studies.