Antioxidant activities
Antioxidant compounds are responsible for scavenging free radicals, which are produced during normal metabolism or during adverse conditions that can be harmful to biological systems and leading to death of an organism. Species like C. inerme have been used as antioxidant drugs in various indigenous systems of medicines (Masuda et al. 1999). Organic and aqueous extracts of C. colebrookianum showed significant inhibition of lipid peroxidation in vitro and in vivo induced by FeSO4-ascorbate in rats. Aqueous extracts showed strongest inhibitory activity over organic extracts. This lends scientific support to the therapeutic use of the plant leaves claimed in tribal medicine (Rajlakshmi et al. 2003). Isoacteoside, trichotomoside and jionoside D, three compounds isolated from C. trichotomum, when tested showed significant scavenging activity of intracellular reactive oxygen species produced by hydrogen peroxide suggesting their antioxidant properties (Chae et al. 2004, 2005, 2006). Apigenin-7-O-β-D-glucuronopyranoside (AGC), isolated from C. trichotomum leaves decreased the volume of gastric juice and increased the gastric pH in a dose-dependent manner, decreasing the number of gastric lesions. A malondialdehyde (MDA) level, which is the end product of lipid peroxidation, was also decreased by AGC (i.d. 3 mg/kg), which increased significantly after the induction of reflux oesophagitis. The MDA levels did not decrease when either apigenin or omeprazole were used as a control suggesting that AGC has an antioxidative mechanism to reduce gastric lesions. Apigenin glucuronopyranoside also decreased mucosal glutathione (GSH) levels significantly suggesting that AGC possesses free radical scavenging activity. So it can be concluded that AGC is more potent in inhibiting reflux oesophagitis and gastritis and may therefore be a promising drug for their treatment (Min et al. 2005). In present lifestyles where stress has taken an unwanted important position leading to excess production of free radicals these natural remedies will prove a support to our biological system to balance metabolism.
กิจกรรมการต้านอนุมูลอิสระ Antioxidant compounds are responsible for scavenging free radicals, which are produced during normal metabolism or during adverse conditions that can be harmful to biological systems and leading to death of an organism. Species like C. inerme have been used as antioxidant drugs in various indigenous systems of medicines (Masuda et al. 1999). Organic and aqueous extracts of C. colebrookianum showed significant inhibition of lipid peroxidation in vitro and in vivo induced by FeSO4-ascorbate in rats. Aqueous extracts showed strongest inhibitory activity over organic extracts. This lends scientific support to the therapeutic use of the plant leaves claimed in tribal medicine (Rajlakshmi et al. 2003). Isoacteoside, trichotomoside and jionoside D, three compounds isolated from C. trichotomum, when tested showed significant scavenging activity of intracellular reactive oxygen species produced by hydrogen peroxide suggesting their antioxidant properties (Chae et al. 2004, 2005, 2006). Apigenin-7-O-β-D-glucuronopyranoside (AGC), isolated from C. trichotomum leaves decreased the volume of gastric juice and increased the gastric pH in a dose-dependent manner, decreasing the number of gastric lesions. A malondialdehyde (MDA) level, which is the end product of lipid peroxidation, was also decreased by AGC (i.d. 3 mg/kg), which increased significantly after the induction of reflux oesophagitis. The MDA levels did not decrease when either apigenin or omeprazole were used as a control suggesting that AGC has an antioxidative mechanism to reduce gastric lesions. Apigenin glucuronopyranoside also decreased mucosal glutathione (GSH) levels significantly suggesting that AGC possesses free radical scavenging activity. So it can be concluded that AGC is more potent in inhibiting reflux oesophagitis and gastritis and may therefore be a promising drug for their treatment (Min et al. 2005). In present lifestyles where stress has taken an unwanted important position leading to excess production of free radicals these natural remedies will prove a support to our biological system to balance metabolism.
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