SGLT2-
mediated glucose reabsorption driving excess sodium
reabsorption might cause volume expansion, and SGLT2
inhibitors would be expected to block this effect.80 This
blocking effect is a potentially powerful mechanism for
protection against heart failure and could be a route
through which an additional component of the
cardiovascular benefit is achieved. The drug class might
also have beneficial effects on the kidney,13 suggesting
another mechanism by which SGLT2 inhibitors might
protect against vascular disease.