Leading authors investigating the function of lysosomal enzymes as anti-inflammatory agents proposed β-Glucuronidase and N-acetyl-β-D-glucosaminidase (NAGase) as possible early indicators for SCM. The enzyme lactate dehydrogenase (LDH) is already in use for quality assurance of cow milk and was also investigated as a possible parameter for infection diseases in goats indicating differences in status of infection. As even light infections of the udder lead to a change in milk composition, ingredients like lactose or lactoferrin (Lf) are also mentioned in studies regarding SCM in goats. Lf has bacteriostatic properties which could indicate an udder infection at an early stage. The paper reviews the recent knowledge about IMI in goats and tried to reflect the published investigations on possible indicators of SCM in goats.