The mainstay of treatment consists of corticosteroids,
often producing rapid improvement in symptomatology
(5). Supportive therapy includes antipyretics, antihistamines,
topical steroids, and topical moisturizers. Relapse
is possible with repeat exposure to the offending drug
and when steroids are tapered or discontinued (5). Family
members of the patient should be counseled as DRESS
syndrome has been described in familial aggregations (2).
In conclusion, DRESS syndrome is a severe hypersensitivity
reaction that has been implicated with numerous
drugs. Early diagnosis and prompt treatment with corticosteroids
is imperative. Emergency physicians should
consider DRESS syndrome when evaluating patients
who present with skin rash and unusual or systemic
complaints in association with any new medication,
particularly antiepileptics.