The increase in ebook sales and popularity, coupled with the decline of print books, raises various points of concern. Will ebooks replace print books? Have people abandoned print for ebooks? Who is likely to adopt ebooks and why? The aim of this study is to address these questions by examining the readership and preferences for ebooks and print books across contexts, which include reading purposes, reading situations, and individual contextual factors such as age, gender, education level, race/ethnicity, income, community type, and Internet use. Additionally, this study aims to identify factors that contribute to ebook adoption. By yielding a better understanding of reader choice and preference for ebooks and print books across contexts, the results of this study will help libraries and information institutions make important decisions on collection acquisition and management. The results will also help libraries, publishers, information system developers, and information providers in general to adapt to another generation of readers.