Design of Experiment (DOE) comprises an array of statistical tools to plan an experiment in order to obtain suitable data for statistical analysis which will then result in meaningful and objective conclusions [13]. This section reports on the use of a DOE tool known as the Paired Comparison Design in order to obtain suitable experimental data for comparing the quality of Sirchie® Hi-Fi black powder and acid-modified IC powder for the developed natural fingermarks on white A4 writing paper and white plastic.