In our continuos search for functional food plants, we designed the present work to investigate in vitro, the antibacterial activity of the methanol extracts of four Cameroonian food plants, Annona muricata Lin. (Annonaceae), Canarium schweinfurthii Engl. (Burseraceae), Colocasia esculenta (L.) Schott (Araceae), Hibiscus esculentus L. (Tiliaceae) and Triumfetta pentandra A.Rich. (Tiliaceae) against MDR Gram-negative bacteria.